VATICAN CITY: Pope Leo XIV on Saturday called on Israel and Iran to show responsiblity and reason, as the two arch-foes clashed in their largest conflict.

“The situation in Iran and Israel has seriously deteriorated at such a delicate moment. I wish to forcefully renew an appeal for responsibility and reason,“ the pope said in a statement.

“The commitment to build a safer world free from the nuclear threat must be pursued through a respectful meeting and sincere dialogue,“ he said. “No-one should ever threaten the existence of the other.”